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Rational design and latest advances of codelivery systems for cancer therapy.
Materials Today Bio ( IF 8.2 ) Pub Date : 2020-05-07 , DOI: 10.1016/j.mtbio.2020.100056
Q Y Meng 1 , H L Cong 1 , H Hu 1 , F-J Xu 2
Affiliation  

Current treatments have limited effectiveness in treating tumors. The combination of multiple drugs or treatment strategies is widely studied to improve therapeutic effect and reduce adverse effects of cancer therapy. The codelivery system is the key to realize combined therapies. It is necessary to design and construct different codelivery systems in accordance with the variable structures and properties of cargoes and vectors. This review presented the typical design considerations about codelivery vectors for cancer therapy and described the current state of codelivery systems from two aspects: different types of vectors and collaborative treatment strategies. The commonly used loading methods of cargoes into the vectors, including physical and chemical processes, are discussed in detail. Finally, we outline the challenges and perspectives about the improvement of codelivery systems.



中文翻译:

癌症治疗代码交付系统的合理设计和最新进展。

目前的治疗方法在治疗肿瘤方面效果有限。广泛研究多种药物或治疗策略的组合以改善治疗效果并减少癌症治疗的不良影响。代码交付系统是实现组合疗法的关键。必须根据货物和载体的可变结构和特性设计和构造不同的代码传递系统。这篇综述介绍了用于癌症治疗的代码传递载体的典型设计注意事项,并从两个方面描述了代码传递系统的当前状态:不同类型的载体和协作治疗策略。详细讨论了将货物装载到向量中的常用方法,包括物理和化学过程。最后,

更新日期:2020-05-07
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