The physiological role of alternative polyadenylation (APA) in controlling hematopoietic stem cell (HSC) behavior in vivo, and the mechanistic implications of this association, remain elusive. Now in Cell Stem Cell, Sommerkamp et al. (2020) provide evidence that APA regulates HSC self-renewal and multi-potency by affecting stem cell activation and glutaminolysis.

中文翻译：

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APA为提高HSC代谢提供了捷径。

替代的聚腺苷酸化（APA）在体内控制造血干细胞（HSC）行为的生理学作用以及这种关联的机制含义仍然难以捉摸。现在在《细胞干细胞》中，Sommerkamp等人。（2020）提供了证据，表明APA通过影响干细胞活化和谷氨酰胺分解来调节HSC的自我更新和多能性。