Nonionic surfactants are highly stable and cost‐effective and receiving acceptance for applications in many diverse fields including drug delivery, due to their distinctive properties. Here, we report on the synthesis and characterization of sulfanilamide‐based nonionic surfactants for nanoscale vesicular drug loading applications. Nonionic surfactants were synthesized through alkylation of sulfanilamide with alkyl halides that possessed diverse degrees of lipophilicity. They were explored for their nanovesicular drug loading with Cefixime as a hydrophobic model drug. Drug‐loaded nanovesicles were characterized for surface morphologies, size, size distribution, surface charge, and drug loading efficiency using atomic force microscopy (AFM), dynamic light scattering (DLS), and UV–visible spectrophotometry. All of the synthesized nonionic surfactants revealed their CMC values in 0.055–0.035 mM range depending upon the lipophilic chain length of surfactants. They caused a decreased hemoglobin release and low toxicity against cell culture. They self‐assembled and loaded an increased amount of drug in the form of nanorange spherical shape niosomal vesicles. Results of the current study verify these synthesized nonionic surfactants are hemocompatible, nontoxic, and capable of self‐assembling into nanorange niosomal vesicles. These niosomal vesicles can be suggested as safe and highly efficient nanocarriers for hydrophobic drug loading and delivery.

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磺胺基非离子表面活性剂的合成，表征及其在纳米囊泡药物中的应用

非离子表面活性剂具有极高的稳定性和成本效益，并因其独特的性能而在包括药物输送在内的许多不同领域得到认可。在这里，我们报告了用于纳米级囊泡药物加载应用的基于磺胺基的非离子表面活性剂的合成和表征。非离子表面活性剂是通过磺酰胺与具有不同程度亲脂性的烷基卤化物烷基化而合成的。用头孢克肟作为疏水模型药物研究了它们的纳米囊泡药物负载量。使用原子力显微镜（AFM），动态光散射（DLS）和紫外可见分光光度法对载药纳米囊的表面形态，大小，大小分布，表面电荷和载药效率进行了表征。所有合成的非离子表面活性剂均显示其CMC值在0.055-0.035 mM范围内，具体取决于表面活性剂的亲脂性链长。它们导致血红蛋白释放减少，并且对细胞培养的毒性低。他们自组装并以纳米范围的球形脂质体形式装载了越来越多的药物。目前的研究结果证明，这些合成的非离子表面活性剂具有血液相容性，无毒性，并且能够自组装成纳米级的脂质体囊泡。这些脂质体囊泡可被建议作为用于疏水性药物装载和递送的安全且高效的纳米载体。他们自组装并以纳米范围的球形脂质体形式装载了越来越多的药物。当前的研究结果证明，这些合成的非离子表面活性剂具有血液相容性，无毒性，并且能够自组装成纳米级的脂质体囊泡。这些脂质体囊泡可被建议作为用于疏水性药物装载和递送的安全且高效的纳米载体。他们自组装并以纳米范围的球形脂质体形式装载了越来越多的药物。目前的研究结果证明，这些合成的非离子表面活性剂具有血液相容性，无毒性，并且能够自组装成纳米级的脂质体囊泡。这些脂质体囊泡可被建议作为用于疏水性药物装载和递送的安全且高效的纳米载体。