Objectives: The aims of this study were to investigate the differences of fasciculations detected by muscle ultrasonography (MUS) among patients with amyotrophic lateral sclerosis (ALS), patients with ALS mimics and healthy controls, and to propose a simplified MUS fasciculation score for the diagnosis of ALS.Methods: We included 16 patients with ALS (ALS group), 10 patients with ALS mimics (disease-control group), and 10 healthy adults (healthy control group). Subjects underwent MUS in 11 muscles, including the tongue, and bilateral upper trapezius, biceps brachii, abductor pollicis brevis, rectus femoris, and tibialis anterior.Results: The number of muscles with fasciculations per person was more in the ALS group (6.44 ± 2.56) than in the disease-control group (1.20 ± 1.87, P = 0.001) and healthy control group (0.50 ± 1.08, P < 0.001). Fasciculations in 3 of 11 muscles could predict the ALS diagnosis with high sensitivity (88.2%) and specificity (94.7%).Conclusions: Fasciculations detected by MUS can be a simple and useful diagnostic tool for ALS.

中文翻译：

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肌肉超声检查对肌萎缩性侧索硬化症的诊断。

目的：本研究的目的是调查肌萎缩侧索硬化症（ALS）患者，ALS模仿者和健康对照者之间通过肌肉超声检查（MUS）检测到的束缚差异，并提出简化的MUS束缚评分以进行诊断方法：我们纳入了16例ALS患者（ALS组），10例ALS模拟患者（疾病对照组）和10例健康成年人（健康对照组）。受试者在11条肌肉中进行了MUS，包括舌头和双侧上斜方肌，肱二头肌，短poll外展肌，股直肌和胫骨前肌。结果：ALS组每人具有束缚的肌肉数量更多（6.44±2.56 ）高于疾病对照组（1.20±1.87，P = 0.001）和健康对照组（0.50±1.08，P <0.001）。