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The interplay between host haemostatic systems and Leptospira spp. infections.
Critical Reviews in Microbiology ( IF 6.5 ) Pub Date : 2020-03-06 , DOI: 10.1080/1040841x.2020.1735299 Monica L Vieira 1 , Heiko Herwald 2 , Ana Lucia T O Nascimento 3
Critical Reviews in Microbiology ( IF 6.5 ) Pub Date : 2020-03-06 , DOI: 10.1080/1040841x.2020.1735299 Monica L Vieira 1 , Heiko Herwald 2 , Ana Lucia T O Nascimento 3
Affiliation
Hemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be considered as an essential bacterial virulence mechanism. Complications that bacterial pathogens can induce are therefore often the consequence of evoked host responses. A comprehensive understanding of the molecular mechanisms triggered in infectious processes may help to develop prophylactic methods and novel therapies for the patients suffering from a particular infectious disease. This review aims to provide a critical updated compiling of recent studies on how the pathogenic Leptospira can interact with and manipulate the host haemostatic systems and the consequences for leptospirosis pathogenesis.
中文翻译:
宿主止血系统与钩端螺旋体之间的相互作用。感染。
止血是一种保护血管系统完整性的防御机制,由凝血级联,纤维蛋白溶解,血小板聚集和血管内皮组成。止血系统除了具有维持血管完整性的主要功能外,还可以与免疫和炎症过程协同作用,以消除微生物感染期间入侵的病原体。因此,在病理表现下,止血必须与炎症反应和免疫反应协调一致地相互作用。几种病原体可以通过针对特定的止血成分以自己的利益为目标来调节这些源自宿主的对策。因此,必须将调节宿主防御系统的能力视为必不可少的细菌毒力机制。因此,细菌病原体可能诱发的并发症通常是诱发的宿主反应的结果。对感染过程中触发的分子机制的全面理解可能有助于为患有特定感染性疾病的患者开发预防方法和新疗法。这篇综述旨在提供有关致病性钩端螺旋体如何与宿主止血系统相互作用和操纵宿主钩端螺旋体系统以及对钩端螺旋体病发病机制的影响的最新研究的重要最新汇编。
更新日期:2020-03-06
中文翻译:
宿主止血系统与钩端螺旋体之间的相互作用。感染。
止血是一种保护血管系统完整性的防御机制,由凝血级联,纤维蛋白溶解,血小板聚集和血管内皮组成。止血系统除了具有维持血管完整性的主要功能外,还可以与免疫和炎症过程协同作用,以消除微生物感染期间入侵的病原体。因此,在病理表现下,止血必须与炎症反应和免疫反应协调一致地相互作用。几种病原体可以通过针对特定的止血成分以自己的利益为目标来调节这些源自宿主的对策。因此,必须将调节宿主防御系统的能力视为必不可少的细菌毒力机制。因此,细菌病原体可能诱发的并发症通常是诱发的宿主反应的结果。对感染过程中触发的分子机制的全面理解可能有助于为患有特定感染性疾病的患者开发预防方法和新疗法。这篇综述旨在提供有关致病性钩端螺旋体如何与宿主止血系统相互作用和操纵宿主钩端螺旋体系统以及对钩端螺旋体病发病机制的影响的最新研究的重要最新汇编。