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Proteomics of pediatric ependymomas: a review.
Child's Nervous System ( IF 1.4 ) Pub Date : 2020-05-06 , DOI: 10.1007/s00381-020-04627-1
George Th Tsangaris 1 , Maria C Anastasoviti 1 , Athanasios K Anagnostopoulos 1
Affiliation  

Ependymomas, affecting both children and adults, are neuroepithelial tumors occurring throughout all compartments of the central nervous system. Pediatric ependymomas arise almost exclusively intracranially and are associated with a poor 10-year overall survival of around 60%. During the last years, the application of multi-omics technologies on the study and understanding of neuro-cancer diseases has become a standard; in this regard, application of these approaches on ependymomas has gained noticeable momentum. The objective of this review article was to summarize all knowledge generated by the application of modern omics approaches with regard to pediatric ependymal tumors, aiming at elucidating molecular mechanisms of oncogenesis as well as identification of pathway strategies that will help in therapeutic intervention.

中文翻译:

小儿室管膜瘤的蛋白质组学:综述。

影响儿童和成人的室间隔膜瘤是发生在中枢神经系统所有部位的神经上皮肿瘤。小儿室间隔膜瘤几乎仅在颅内发生,并伴有10%的约60%的总生存期差。在过去的几年中,多组学技术在神经癌疾病的研究和理解中的应用已成为标准。在这方面,这些方法在室管膜瘤上的应用获得了明显的发展。这篇综述文章的目的是总结有关小儿室管膜肿瘤的现代组学方法应用所产生的所有知识,旨在阐明肿瘤发生的分子机制以及确定有助于治疗干预的途径策略。
更新日期:2020-05-06
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