This study presents the statistical results of patients who had been recently discharged from hospital within one month after their treatment in the emergency department (ED). Using routine (14,881) MCV and RDW measurements and statistical tools, we could predict acute mortality in these patients (N = 1158), adjusted for age. It is likely that an increase in the MCV and RDW parameters may correlate in some of our older patients with a poor prognosis with an increased level of circulating IGF–I, which affects red blood cell parameters. The research presents the prognostic statistics of the analyzed clinical factors as well as speculates on the potential correlation of these parameters with the regenerative potential of stem-cell compartment. Analysis shows that both MCV and RDW are statistically significant (Area Under Curve [AUC], lower CI 95% >50%) predictors of acute mortality in ED patients. The classification of patients based on their MCV threshold (= 92.2 units) indicates a proper clinical prognosis in nearly 6 of 10 subjects (AUC >58%), whereas taking into account RDW (=13.8%) indicates a proper clinical prognosis in no more than 7 of 10 individuals. The report concludes that by employing strongly fitting (95%) quadratic modeling of the ORs against the biomarkers studied, one can notice a similar relationship between MCV and RDW as diagnostic tools to predict regenerative potential and clinical outcomes in older patients. Although RDW alone had a 10% higher diagnostic value in terms of predicting early death in the emergency department in patients that were admitted to the ED and subsequently hospitalized, also taking the MCV measurement improved accuracy in predicting clinical outcomes by 2.5% compared to RDW alone.

中文翻译：

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红细胞平均体细胞体积（MCV）和红血分布宽度（RDW）参数作为老年患者再生潜能的潜在指标和急性死亡率的预测因子-初步报告。

这项研究提供了在急诊科（ED）治疗后一个月内刚出院的患者的统计结果。使用常规的（14,881）MCV和RDW测量和统计工具，我们可以预测这些患者的急性死亡率（N = 1158），根据年龄进行了调整。MCV和RDW参数的增加可能与某些预后较差的老年患者与循环IGF–I水平升高相关，这会影响红细胞参数。该研究提供了所分析的临床因素的预后统计数据，并推测了这些参数与干细胞区室的再生潜力之间的潜在相关性。分析表明，MCV和RDW都是ED患者急性死亡的统计学显着性指标（曲线下面积[AUC]，CI较低下95％> 50％）。根据其MCV阈值（= 92.2个单位）对患者进行分类表明，在10名受试者中有近6名（AUC> 58％）有适当的临床预后，而考虑了RDW（= 13）。8％）的患者预示着正确的临床预后（不超过10个人中的7个人）。该报告的结论是，通过对所研究的生物标记物进行ORs的强拟合（95％）二次建模，可以注意到MCV和RDW之间的相似关系作为预测老年患者再生潜力和临床结果的诊断工具。尽管就预测急诊入院急诊并随后住院的患者而言，仅RDW的诊断价值就高10％，但与单独RDW相比，采用MCV测量将预测临床结局的准确性提高了2.5％ 。人们可以注意到MCV和RDW之间的相似关系，可以作为诊断工具来预测老年患者的再生潜力和临床结果。尽管就预测急诊入院急诊并随后住院的患者而言，仅RDW的诊断价值就高10％，但与单独RDW相比，采用MCV测量将预测临床结局的准确性提高了2.5％ 。人们可以注意到MCV和RDW之间的相似关系，可以作为诊断工具来预测老年患者的再生潜力和临床结果。尽管就预测急诊入院急诊并随后住院的患者而言，仅RDW的诊断价值就高10％，但与单独RDW相比，采用MCV测量将预测临床结局的准确性提高了2.5％ 。