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Synthesis of deuterium-labeled rosuvastatin calcium
Journal of Radioanalytical and Nuclear Chemistry ( IF 1.6 ) Pub Date : 2020-05-06 , DOI: 10.1007/s10967-020-07165-x
Lei Tian , Li Xu , Jian Li , Mei He

The stable isotope-labeled rosuvastatin was requested in order to fully understand the metabolic process of rosuvastatin. An effective synthesis approach was developed for [2H4] rosuvastatin calcium. After ten steps, [2H4] rosuvastatin calcium was prepared with excellent chemical purification and isotope enrichment which can be applied as an internal standard. Moreover, this synthesis method could be useful in synthesis of other statins.

中文翻译:

氘标记瑞舒伐他汀钙的合成

为了全面了解瑞舒伐他汀的代谢过程,需要稳定同位素标记的瑞舒伐他汀。为 [2H4] 瑞舒伐他汀钙开发了一种有效的合成方法。经过十个步骤后,[2H4] 瑞舒伐他汀钙得到了出色的化学纯化和同位素富集,可用作内标。此外,这种合成方法可用于合成其他他汀类药物。
更新日期:2020-05-06
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