Mesenchymal stem cells (MSCs) possess the capabilities of self-renewal and multipotent differentiation. Firstly isolated from bone marrow, MSCs are subsequently identified from various post-natal tissue types. Based the differentiation into tissue-specific cells, MSCs were capable of replacing damaged and diseased tissues. In addition, MSCs have been demonstrated to possess important immunomodulatory properties. Increasing data showed that MSCs exhibited tropism for sites of the tumor microenvironment and interacted with tumor cells closely through paracrine signaling. Therefore, better understanding of crosstalk between MSCs and tumor cells will be able to develop potential strategies in the treatment of tumors in the future. Herein, we summarize the research progress of the influence of MSCs on tumor cells and the prospect of their application in tumor therapy in this review.

中文翻译：

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间充质干细胞与肿瘤之间的相互作用和潜在的应用。

间充质干细胞（MSCs）具有自我更新和多能分化的能力。首先从骨髓中分离出来，然后从各种产后组织类型中鉴定出MSC。基于向组织特异性细胞的分化，MSC能够替换受损和患病的组织。另外，已经证明MSC具有重要的免疫调节特性。越来越多的数据表明，MSC在肿瘤微环境部位表现出向性性，并通过旁分泌信号传导与肿瘤细胞紧密相互作用。因此，更好地了解MSC与肿瘤细胞之间的串扰将能够在将来开发治疗肿瘤的潜在策略。在这里