We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = -0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a "metabolic-oxidative stress factor" comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.

中文翻译：

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氧化应激和炎症标志物PTX3，CypA和HB-EGF：在STEMI患者中如何关联？

我们调查了炎性生物标志物五环素3（PTX3），亲环蛋白A（CypA）和肝素结合表皮生长因子样生长因子（HB-EGF）的循环水平；氧化应激 和ST段抬高的急性心肌梗死（STEMI）患者中的抗氧化剂和抗氧化剂状态标记，以更好地了解炎症与氧化应激之间的关系。我们检查了氧化应激对炎性参数高值的影响。该研究包括87例STEMI患者和193例对照。我们观察到PTX3与HB-EGF（ρ= 0.24，P = .027），CyPA和巯基（SH）组之间呈正相关（ρ= 0.25，P = .026），PTX3与SH组之间呈负相关STEMI患者中（ρ= -0.35，P = .001）。为了更好地了解所检查参数对高浓度炎症参数发生的影响，我们使用主成分分析对它们进行了分组。该分析确定了4个最重要的因素。对于PTX3和HB-EGF，计算了区分STEMI患者和对照的最佳临界值。PTX3高于临界值的独立预测因子是“代谢-氧化应激因子”，由葡萄糖和氧化应激标记物的抗氧化剂-抗氧化剂平衡组成（比值比为4.449，P = .030）。结果表明，STEMI患者具有更高的代谢和氧化应激状态值时，PTX3值会更高。对于PTX3和HB-EGF，计算了区分STEMI患者和对照的最佳临界值。PTX3高于临界值的独立预测因素是“代谢-氧化应激因子”，该因子由葡萄糖和氧化应激标记物的抗氧化剂-抗氧化剂平衡组成（比值= 4.449，P = .030）。结果表明，STEMI患者具有更高的代谢和氧化应激状态值时，PTX3值会更高。对于PTX3和HB-EGF，计算了区分STEMI患者和对照的最佳临界值。PTX3高于临界值的独立预测因子是“代谢-氧化应激因子”，由葡萄糖和氧化应激标记物的抗氧化剂-抗氧化剂平衡组成（比值比为4.449，P = .030）。结果表明，STEMI患者具有更高的代谢和氧化应激状态值时，PTX3值会更高。