Landscape of genomic imprinting and its functions in the mouse mammary gland,Journal of Molecular Cell Biology

当前位置： X-MOL 学术 › J. Mol. Cell Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Landscape of genomic imprinting and its functions in the mouse mammary gland
Journal of Molecular Cell Biology ( IF 5.5 ) Pub Date : 2020-05-05 , DOI: 10.1093/jmcb/mjaa020
Haibo Xu _{1,

2} , Lina Zhao _{1,

2} , Xu Feng ₁ , Yujie Ma ₁ , Wei Chen ₁ , Li Zou ₁ , Qin Yang ₁ , Jihong Sun ₃ , Hong Yu ₄ , Baowei Jiao _{1,

5,

6}

Affiliation

Abstract

Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic imprinting remain limited. In this study, we found that both the number of IGs and their expression levels decreased during development of the mouse mammary gland. IG expression was lineage-specific and related to mammary gland development and lactation. Meta-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell stemness and differentiation, which was confirmed by our functional studies. Accordingly, our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland maturity. Taken together, our findings revealed the importance of IGs in a poorly studied nutrition-related organ, i.e. the mammary gland, thus providing a reference for further studies on genomic imprinting.

更新日期：2020-05-05

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>