Abstract Obesity is a foremost health issue that affects about 1.6 million people out of which 400 million worldwide. Epidemiological evidences prove obesity is the primary cause for various metabolic ailments e.g. diabetes. Poria cocos possess extensive biological actions, for instance, antioxidant, anti-inflammatory, antitumor, immunomodulatory actions. The primary limitation of all phytomedicine was their poor bioavailability hence in this investigation, we bio-fabricated the gold nanoparticles from Poria cocos aqueous extract and inspected their potency to treat obesity. Obese rat model were produced via fed the young female rats with high fat food for 8 weeks regimen. Further to confirm the potency of Poria cocos gold nanoparticles against obesity induced metabolic disorders we treated obese rats with low dose streptozotocin in the conclusion of the investigational time. The synthesis of Poria cocos gold-nanoparticles was evidenced via the UV-Spectroscopic study and characterized with SEM, TEM and EDAX studies. The anti-obesity actions of Poria cocos gold-nanoparticles were investigated by estimating the glucose profile, kidney markers, lipid profile, inflammatory cytokines, adipocyte markers, antioxidants in the Poria cocos gold nanoparticles treated obese rats. To confirm the Poria cocos gold nanoparticles role on inhibiting the obesity induced metabolic disorders we analyzed the histopathological changes in cardiac tissues. Our physical characterization confirms the synthesized Poria cocos gold nanoparticles assure the distinctions of influential nanoparticles to be utilized for the treatment. The results from biochemical and histopathological analysis confirms Poria cocos gold nanoparticles is a persuasive antidiabetic, anti-inflammatory, antioxidant, anti-obesity drug. Overall our results authentically confirm Poria cocos gold nanoparticles is a potent anti-obesity drug and it also protects from obesity induced metabolic disorders.

中文翻译：

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茯苓合成的金纳米粒子调节高脂饮食和链脲佐菌素诱导的肥胖糖尿病大鼠模型中的抗肥胖参数

摘要 肥胖是最重要的健康问题，全世界约有 4 亿人，其中约有 160 万人受到影响。流行病学证据证明肥胖是导致糖尿病等各种代谢疾病的主要原因。茯苓具有广泛的生物学作用，例如抗氧化、抗炎、抗肿瘤、免疫调节作用。所有植物药的主要限制是它们的生物利用度差，因此在本研究中，我们从茯苓水提取物中生物制造了金纳米粒子，并检查了它们治疗肥胖症的效力。雌性幼鼠高脂肪食物喂养8周制得肥胖大鼠模型。为了进一步证实茯苓金纳米颗粒对肥胖诱导的代谢紊乱的效力，我们在研究时间结束时用低剂量链脲佐菌素治疗肥胖大鼠。茯苓金纳米颗粒的合成通过紫外光谱研究得到证实，并通过 SEM、TEM 和 EDAX 研究进行表征。通过估计茯苓金纳米颗粒治疗肥胖大鼠的葡萄糖谱、肾脏标志物、脂质谱、炎性细胞因子、脂肪细胞标志物、抗氧化剂，研究了茯苓金纳米颗粒的抗肥胖作用。为了证实茯苓金纳米粒子在抑制肥胖引起的代谢紊乱方面的作用，我们分析了心脏组织的组织病理学变化。我们的物理表征证实合成的茯苓金纳米粒子确保了用于治疗的有影响的纳米粒子的区别。生化和组织病理学分析结果证实，茯苓金纳米粒子是一种有说服力的抗糖尿病、抗炎、抗氧化、抗肥胖药物。总的来说，我们的结果真实地证实了茯苓金纳米粒子是一种有效的抗肥胖药物，它还可以防止肥胖引起的代谢紊乱。