Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic activities, providing a direct path for fluctuations in metabolite availability to regulate the epigenome. Over the past decade, our knowledge of this link has grown significantly. What began with studies showing that cofactor availability drives global abundances of chromatin modifications has transitioned to discoveries highlighting metabolic enzymes as loci-specific regulators of gene expression. Here, we cover our current understanding of mechanisms that facilitate the dynamic and complex relationship between metabolism and the epigenome, focusing on the roles of essential metabolic and chromatin associated enzymes. We discuss physiological conditions where availability of these epimetabolites is dynamically altered, highlighting known links to the epigenome and proposing other plausible connections.

许多染色质修饰酶需要代谢辅因子来支持其催化活性，从而为调节表观基因组的代谢物可用性波动提供了直接途径。在过去十年中，我们对这种联系的了解显着增加。最初的研究表明辅因子的可用性驱动了染色质修饰的全球丰度，现已转变为强调代谢酶作为基因表达的位点特异性调节剂的发现。在这里，我们涵盖了我们目前对促进代谢和表观基因组之间动态和复杂关系的机制的理解，重点是基本代谢和染色质相关酶的作用。我们讨论了这些表观代谢物的可用性动态改变的生理条件，