The presence of actin in the nucleus has been a matter of debate for many years. In recent years many important roles of actin in the nucleus (transcriptional regulation, chromatin remodeling, DNA repair, cell division, maintenance of nuclear architecture) have been identified, and the precise control of nuclear actin levels has been demonstrated. The vital importance of the actin driven processes in the cell make it highly likely that dysregulation of nuclear actin dynamics and structure can be linked to tumor induction and -progression. In this chapter I summarize our current knowledge about nuclear actin in the cancer context.

中文翻译：

---

癌症生物学中的核肌动蛋白。

多年来，细胞核中肌动蛋白的存在一直是一个争论不休的问题。近年来，肌动蛋白在细胞核中的许多重要作用（转录调节、染色质重塑、DNA 修复、细胞分裂、核结构的维持）已被确定，并且已经证明了对核肌动蛋白水平的精确控制。细胞中肌动蛋白驱动过程的重要性使得核肌动蛋白动力学和结构的失调极有可能与肿瘤诱导和进展有关。在本章中，我总结了我们目前对癌症背景下核肌动蛋白的了解。