OBJECTIVE(S) To identify clinical predictors of future eating disorder symptoms in women with polycystic ovary syndrome (PCOS). DESIGN Prospective cohort study. SETTING University center. PATIENT(S) One hundred sixty-four women with PCOS by the Rotterdam criteria. INTERVENTION(S) Participants were characterized at a baseline visit between 2006 and 2017. A questionnaire including the validated Eating Disorder Examination-Questionnaire (EDE-Q) was self-administered at follow-up. MAIN OUTCOME MEASURE(S) EDE-Q global score (0-6, higher scores indicate more severe symptoms). RESULT(S) One hundred sixty-four women completed the follow-up survey an average of 5.3 years after the baseline visit. Compared with a normative population, women with PCOS had higher EDE-Q global scores (2.3 vs. 1.5) and scored higher on all subscales. Within the PCOS cohort, the following baseline clinical characteristics were independently predictive of scoring in the highest EDE-Q global score tertile: body mass index, waist circumference, hyperandrogenemia, high sensitivity C-reactive protein, and depression scores. Obesity at baseline conferred a 6.9-fold increase in the odds of elevated EDE-Q score (adjusted odds ratio = 6.89; 95% confidence interval, 2.70, 17.62), while a positive depression screen conferred 3.6-fold increased odds (adjusted odds ratio = 3.58; 95% confidence interval, 1.74-7.35). Compared with white women, nonwhite women were at risk of higher EDE-Q scores. CONCLUSION(S) Women with PCOS are at risk of disordered eating attitudes and behaviors, which may interfere with attempts at lifestyle interventions. Clinicians should screen women with PCOS for eating disorder psychopathology, especially those with obesity or depression. An exclusive focus on weight loss may have unintended consequences.

中文翻译：

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肥胖和抑郁是多囊卵巢综合征女性未来饮食失调相关态度和行为的危险因素

目的（S）确定多囊卵巢综合征（PCOS）女性未来饮食失调症状的临床预测因素。设计前瞻性队列研究。设置大学中心。患者 (S) 164 名符合鹿特丹标准的 PCOS 女性。干预措施 参与者在 2006 年至 2017 年的基线访视中进行了表征。包括经过验证的饮食失调检查问卷 (EDE-Q) 的问卷在随访时自我管理。主要结局指标 EDE-Q 总体评分（0-6，分数越高表示症状越严重）。结果 164 名女性在基线访问后平均 5.3 年完成了后续调查。与正常人群相比，PCOS 女性的 EDE-Q 总体得分更高（2.3 对 1.5），并且在所有分量表上的得分都更高。在 PCOS 队列中，以下基线临床特征可独立预测最高 EDE-Q 总体评分三分位数：体重指数、腰围、高雄激素血症、高敏 C 反应蛋白和抑郁评分。基线时的肥胖使 EDE-Q 评分升高的几率增加了 6.9 倍（调整后的优势比 = 6.89；95% 置信区间，2.70、17.62），而积极的抑郁筛查使增加的几率（调整后的优势比）增加了 3.6 倍= 3.58；95% 置信区间，1.74-7.35)。与白人女性相比，非白人女性的 EDE-Q 得分风险更高。结论 (S) 患有 PCOS 的女性有饮食态度和行为紊乱的风险，这可能会干扰生活方式干预的尝试。临床医生应筛查患有 PCOS 的女性的饮食失调精神病理学，尤其是那些肥胖或抑郁的人。专注于减肥可能会产生意想不到的后果。