Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates inflammatory responses and the immune environment and subsequently facilitates immune escape of cancer cells, thus promoting tumor development and progression. Efferocytosis is an equilibrium formed by perfect coordination among "find-me", "eat-me" and "don't-eat-me" signals. These signaling pathways not only affect the proliferation, invasion, metastasis, and angiogenesis of tumor cells but also regulate adaptive responses and drug resistance to antitumor therapies. Therefore, efferocytosis-related molecules and pathways are potential targets for antitumor therapy. Besides, supplementing conventional chemotherapy, radiotherapy and other immunotherapies with efferocytosis-targeted therapy could enhance the therapeutic efficacy, reduce off-target toxicity, and promote patient outcome. Video abstract.

中文翻译：

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胞吞作用的调节作为一种新的癌症疗法。

Efferocytosis 是凋亡细胞的生理吞噬清除，它调节炎症反应和免疫环境，随后促进癌细胞的免疫逃逸，从而促进肿瘤的发展和进展。Efferocytosis 是“find-me”、“eat-me”和“don't-eat-me”信号之间完美协调形成的平衡。这些信号通路不仅影响肿瘤细胞的增殖、侵袭、转移和血管生成，还调节抗肿瘤治疗的适应性反应和耐药性。因此，胞吞作用相关的分子和通路是抗肿瘤治疗的潜在靶点。此外，在常规化疗、放疗等免疫疗法的基础上，辅以细胞增多症靶向治疗，可以提高治疗效果，降低脱靶毒性，促进患者预后。视频摘要。