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Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives.
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2020-07-31 , DOI: 10.2174/1389557520666200505124922
M İhsan Han 1 , Ş Güniz Küçükgüzel 2
Affiliation  

This review explains the effects of naproxen and the naproxen moiety in important biological activities. Naproxen, 2-(6-methoxynaphthalen-2-yl)propionic acid, is one of the most utilized propionic acid derivatives to the cure of many injuries or pains. Naproxen is a non-steroidal antiinflammatory drug (NSAID), which is generally used among the NSAIDs. Even though it has gastrointestinal side effects, naproxen has been safely used for many years because of the good cardiovascular sight. In the past years, except for anti-inflammatory effects, other pharmacological activities of naproxen, especially anticancer and antimicrobial activities, gain the attention of researchers. Naproxen shows its activity by inhibiting the COX-2 enzyme. There is significant interest in the possibility that COX-2 inhibitors might retard or prevent the development of various cancer types, which is often characterized by COX-2 expression. The activities of both naproxen and new molecules derived from naproxen were frequently investigated.



中文翻译:

萘普生和萘普生衍生物的抗癌和抗菌活性。

这篇综述解释了萘普生和萘普生部分在重要的生物活性中的作用。萘普生2-(6-甲氧基萘-2-基)丙酸是治疗许多伤害或疼痛最常用的丙酸衍生物之一。萘普生是一种非甾体抗炎药(NSAID),通常在NSAID中使用。尽管萘普生具有胃肠道副作用,但由于具有良好的心血管视力,因此已被安全使用多年。在过去的几年中,除萘普生外,除抗炎作用外,其他药理活性,特别是抗癌和抗菌活性也引起了研究人员的注意。萘普生通过抑制COX-2酶显示其活性。人们对COX-2抑制剂可能延迟或阻止各种癌症类型发展的可能性非常感兴趣,这通常以COX-2表达为特征。萘普生和衍生自萘普生的新分子的活性经常被研究。

更新日期:2020-08-21
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