Chronic pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are major causes of death and reduced quality of life. Characteristic of chronic pulmonary disease is excessive lung inflammation that occurs in response to exposure to inhaled irritants, chemicals, and allergens. Chronic inflammation leads to remodeling of the airways that includes excess mucus secretion, proliferation of smooth muscle cells, increased deposition of extracellular matrix proteins and fibrosis. Protein kinases have been implicated in mediating inflammatory signals and airway remodeling associated with reduced lung function in chronic pulmonary disease. This review will highlight the role of protein kinases in the lung during chronic inflammation and examine opportunities to use protein kinase inhibitors for the treatment of chronic pulmonary diseases.

中文翻译：

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激酶抑制剂治疗阻塞性肺疾病。

慢性肺病，包括慢性阻塞性肺病 (COPD) 和哮喘，是导致死亡和生活质量下降的主要原因。慢性肺部疾病的特征是过度肺部炎症，这是由于暴露于吸入的刺激物、化学物质和过敏原而发生的。慢性炎症导致气道重塑，包括粘液分泌过多、平滑肌细胞增殖、细胞外基质蛋白沉积增加和纤维化。蛋白激酶参与介导炎症信号和与慢性肺病肺功能降低相关的气道重塑。