The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.

中文翻译：

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FALC 基质细胞为监测浆液腔定义了一个独特的免疫生态位。

浆液腔包含专门的脂肪组织，其中包含称为脂肪相关淋巴簇 (FALC) 的免疫细胞小簇。流体从浆液腔通过 FALC 的持续流动使它们成为清除液相污染物和在感染和炎症期间引发局部保护性免疫反应的独特生态位。FALC 在稳态和炎症后的发育和激活是由间皮和成纤维基质细胞群与免疫细胞的密切相互作用来协调的。在这篇综述中，我们讨论了 FALC 基质细胞生物学的最新进展，并强调了 FALC 基质和免疫细胞之间发生的关键相互作用。