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Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia.
Behavioural Neurology ( IF 2.8 ) Pub Date : 2020-04-14 , DOI: 10.1155/2020/4683573
Juan J G Meilán 1, 2 , Francisco Martínez-Sánchez 3 , Israel Martínez-Nicolás 1, 2 , Thide E Llorente 1, 2 , Juan Carro 1, 2
Affiliation  

This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Our aim has been to ascertain whether the typical speech patterns of people with Alzheimer’s disease are also present during the disorder’s preclinical stages. To do so, we shall be using a task that involves reading out aloud. This is followed by an analysis of the recordings, looking for the possible parameters differentiating between those older people with MCI and a high probability of developing dementia and those with MCI that will not do so. We found that the disease’s most differentiating parameters prior to its onset involve changes in speech duration and an alteration in rhythm rate and intensity. These parameters seem to be related to the first difficulties in lexical access among older people with AD.

中文翻译:

非变性轻度认知障碍和临床前痴呆症患者的语音节律变化。

这项研究探讨了与轻度认知障碍有关的几种语音参数,以及可能标志着潜在的神经退行性过程存在的语音参数。语音是一种出色的生物标记,因为它不是侵入性的,而且其分析是快速且经济的。我们的目的是确定在疾病的临床前阶段是否也存在阿尔茨海默氏病患者的典型言语模式。为此,我们将使用一项涉及朗读的任务。接下来是对记录的分析,寻找可能的参数来区分那些患有MCI的老年人和罹患痴呆症的高概率人群以及那些不会患有MCI的老年人。我们发现该疾病发作前最有区别的参数涉及语音持续时间的变化以及节律率和强度的改变。这些参数似乎与AD老年人在词汇访问方面的第一个困难有关。
更新日期:2020-04-14
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