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Stromal cell control of conventional and ectopic germinal centre reactions.
Current Opinion in Immunology ( IF 7 ) Pub Date : 2020-04-20 , DOI: 10.1016/j.coi.2020.03.007
Alyssa Silva-Cayetano 1 , Michelle A Linterman 1
Affiliation  

The germinal centre (GC) is a specialized cellular structure that forms in response to antigenic stimulation. It generates long-term humoral immunity through the production of memory B cells and long-lived antibody-secreting plasma cells. Conventional GCs form within secondary lymphoid organs, where networks of specialised stromal cells that form during embryogenesis act as the stage upon which the various GC immune cell players are brought together, nurtured and co-ordinated to generate a productive response. In non-lymphoid organs, ectopic GCs can form in response to persistent antigenic and inflammatory stimuli. Unlike secondary lymphoid tissues, non-lymphoid organs do not have a developmentally programmed stromal cell network capable of supporting the germinal centre reaction; therefore, the local tissue stroma must be remodelled by inflammatory stimuli in order to host a GC reaction. These ectopic GCs produce memory B cells and plasma cells that form a critical component of the humoral immune response.

中文翻译:

常规和异位生发中心反应的基质细胞控制。

生发中心 (GC) 是响应抗原刺激而形成的特殊细胞结构。它通过产生记忆 B 细胞和长寿命的分泌抗体的浆细胞来产生长期的体液免疫。传统的 GC 在次级淋巴器官内形成,在胚胎发生过程中形成的特化基质细胞网络充当各种 GC 免疫细胞参与者聚集在一起、培养和协调以产生生产性反应的阶段。在非淋巴器官中,异位 GC 可以响应持续的抗原和炎症刺激而形成。与次级淋巴组织不同,非淋巴器官没有发育程序化的基质细胞网络,能够支持生发中心反应。所以,局部组织基质必须通过炎症刺激进行重塑,才能引发 GC 反应。这些异位 GC 产生记忆 B 细胞和浆细胞,它们构成了体液免疫反应的关键组成部分。
更新日期:2020-04-20
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