Secondary lymphoid organs are critical for efficient interaction between innate antigen presenting cells and adaptive lymphocytes in order to start adaptive immune responses. The efficiency by which these cellular subsets meet is highly increased by the orchestrating role of stromal cells within the secondary lymphoid organs. These cells provide cytokines, chemokines and cell surface receptors necessary for survival and guided migration. This increases the likelihood that antigen specific adaptive immune responses occur. Already from initial formation of secondary lymphoid organs, the interaction of immune cells with stromal cells is crucial and this interaction continues during immune activation. With the recent discovery of many stromal cell subsets new immune micro-niches with specific functions that are orchestrated by stromal cells will be discovered. Here, we will discuss how the development of lymph nodes as well as their specific niches is guided by the interaction of immune cells and stromal cells.

中文翻译：

---

基质细胞和免疫细胞参与淋巴结及其生态位的形成。

次级淋巴器官对于先天抗原呈递细胞和适应性淋巴细胞之间的有效相互作用至关重要，以启动适应性免疫反应。基质细胞在次级淋巴器官中的协调作用大大提高了这些细胞亚群相遇的效率。这些细胞提供生存和引导迁移所必需的细胞因子、趋化因子和细胞表面受体。这增加了发生抗原特异性适应性免疫反应的可能性。从次级淋巴器官的初始形成开始，免疫细胞与基质细胞的相互作用就至关重要，并且这种相互作用在免疫激活过程中继续存在。随着最近发现许多基质细胞亚群，将发现具有由基质细胞协调的特定功能的新免疫微生态位。在这里，我们将讨论免疫细胞和基质细胞的相互作用如何指导淋巴结及其特定生态位的发育。