Synaptotagmin 7 (Syt7) is a multifunctional calcium sensor expressed throughout the body. Its high calcium affinity makes it well suited to act in processes triggered by modest calcium increases within cells. In synaptic transmission, Syt7 has been shown to mediate asynchronous neurotransmitter release, facilitation, and vesicle replenishment. In this review we provide an update on recent developments, and the newly emerging roles of Syt7 in frequency invariant synaptic transmission and in suppressing spontaneous release. Additionally, we discuss Syt7's regulation of membrane fusion in non-neuronal cells, and its involvement in disease. How such diversity of functions is regulated remains an open question. We discuss several potential factors including temperature, presynaptic calcium signals, the localization of Syt7, and its interaction with other Syt isoforms.

中文翻译：

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Synaptotagmin-7 在调节囊泡融合中的多种作用。

Synaptotagmin 7 (Syt7) 是一种在全身表达的多功能钙传感器。其高钙亲和力使其非常适合在细胞内钙适度增加所触发的过程中发挥作用。在突触传递中，Syt7 已被证明可以介导异步神经递质释放、促进和囊泡补充。在这篇综述中，我们提供了最新进展的最新进展，以及 Syt7 在频率不变突触传递和抑制自发释放中新出现的作用。此外，我们还讨论了 Syt7 对非神经元细胞膜融合的调节及其与疾病的关系。如何监管如此多样化的职能仍然是一个悬而未决的问题。我们讨论了几个潜在因素，包括温度、突触前钙信号、Syt7 的定位、