Twin studies are one of the main tools for studying the interaction between genes and the environment in the development of complex diseases such as cancers, cardiovascular diseases and diabetes. The Isfahan Twin Registry (ITR) was launched in Isfahan in 2017 as a pilot study to establish a nationwide twin registry in Iran and aims to obtain comprehensive information about complex diseases and their risk factors from twins and multiples living in Isfahan. ITR will continue to recruit twins and multiples until all twins residing in Isfahan are registered in the registry. Twins are identified from welfare agencies, public health homes, maternity hospitals, Persian Twins Association and the local media. Demographic information, twin similarities, lifestyle, family history of diseases and past medical history are collected using validated questionnaires. Anthropometric measurements and blood pressure are measured by health professionals. Hematology panel, fasting blood sugar, total cholesterol, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, alanine aminotransferase and quantitative C-reactive protein are measured by an automated analyzer. Extra samples are obtained for future studies. For twins aged under 6 years, parents complete the questionnaires for their children and a brief questionnaire for themselves. Currently, 998 persons (395 pairs and 67 multiples) are registered in the ITR and have provided their data. Results of preliminary data analysis are discussed in this article. We plan to carry out longitudinal assessments. ITR can play an important role in future epigenetic, biomarkers and omics studies using the biobank materials.

孪生研究是研究复杂疾病（如癌症，心血管疾病和糖尿病）发展过程中基因与环境之间相互作用的主要工具之一。伊斯法罕双胞胎登记系统（ITR）于2017年在伊斯法罕启动，是一项试点研究，旨在在伊朗建立全国性的双胞胎登记系统，旨在从居住在伊斯法罕的双胞胎和多胞胎获得有关复杂疾病及其危险因素的综合信息。ITR将继续招募双胞胎和双胞胎，直到居住在伊斯法罕的所有双胞胎都在注册表中注册。双胞胎来自福利机构，公共卫生院，妇产医院，波斯双胞胎协会和当地媒体。人口统计信息，双胞胎相似性，生活方式，使用经过验证的问卷收集疾病的家族病史和既往病史。人体测量和血压由卫生专业人员测量。血液学组，空腹血糖，总胆固醇，低密度脂蛋白，高密度脂蛋白，天冬氨酸转氨酶，丙氨酸转氨酶和定量C反应蛋白通过自动化分析仪进行测量。获得了额外的样本以供将来研究。对于6岁以下的双胞胎，父母为他们的孩子填写问卷，并为自己填写一份简短的问卷。目前，有998人（395对和67的倍数）在ITR中注册并提供了他们的数据。本文讨论了初步数据分析的结果。我们计划进行纵向评估。