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Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Current Alzheimer Research ( IF 2.1 ) Pub Date : 2020-01-01 , DOI: 10.2174/1567205017666200317092310
Dubravka S Strac 1 , Marcela Konjevod 1 , Matea N Perkovic 1 , Lucija Tudor 1 , Gordana N Erjavec 1 , Nela Pivac 1
Affiliation  

BACKGROUND Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease. OBJECTIVE The aim of the article was to provide a comprehensive overview of the literature on the involvement of DHEA and DHEAS in Alzheimer's disease. METHODS PubMed and MEDLINE databases were searched for relevant literature. The articles were selected considering their titles and abstracts. In the selected full texts, lists of references were searched manually for additional articles. RESULTS We performed a systematic review of the studies investigating the role of DHEA and DHEAS in various in vitro and animal models, as well as in patients with Alzheimer's disease, and provided a comprehensive discussion on their potential preventive and therapeutic applications. CONCLUSION Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer's disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment. However, so far small clinical trials brought little evidence to support their therapy in AD. Therefore, large-scale human studies are needed to elucidate the specific effects of DHEA and DHEAS and their mechanisms of action, prior to their applications in clinical practice.

中文翻译:

阿尔茨海默氏病中的脱氢表雄酮(DHEA)及其硫酸盐(DHEAS)。

背景技术神经甾体脱氢表雄酮(DHEA)和硫酸脱氢表雄酮(DHEAS)参与许多重要的脑功能,包括神经元可塑性和存活,认知和行为,证明了在包括阿尔茨海默氏病在内的不同神经精神病学和神经退行性疾病中的预防和治疗潜力。目的本文的目的是提供有关DHEA和DHEAS参与阿尔茨海默氏病的文献的全面概述。方法在PubMed和MEDLINE数据库中搜索相关文献。选择文章时要考虑其标题和摘要。在所选的全文中,手动搜​​索了参考文献列表以查找其他文章。结果我们对研究DHEA和DHEAS在各种体外和动物模型以及阿尔茨海默氏病患者中的作用的研究进行了系统的综述,并对它们的潜在预防和治疗应用进行了全面讨论。结论尽管结果参差不齐,但各种临床前研究的结果普遍支持DHEA和DHEAS参与阿尔茨海默氏病的病理生理,显示出这些类固醇在预防和治疗中的潜在益处。但是,到目前为止,小型临床试验几乎没有证据支持其在AD中的治疗。因此,在将其应用于临床之前,需要进行大规模的人体研究以阐明DHEA和DHEAS的特定作用及其作用机理。
更新日期:2020-01-01
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