BACKGROUND Sodium valproate (VPA) is considered as the drug of choice for the treatment of generalized epilepsy in children. Sodium Valproate may be hepatotoxic. AIM To assess the level of derangement of liver enzymes in children with epilepsy on treatment with sodium valproate. METHODS A cohort study. One hundred fifty-three children, comprising 51 with epilepsy on treatment with VPA (group I), 51 with epilepsy on treatment with other antiepileptic drugs (AEDs) but not VPA (group II), and 51 with nonconvulsive disorders (group III) had liver function tests performed for them. Data were analyzed by SPSS version 23.0. RESULTS There were 85 males and 68 females, aged 6 months to 14 years (median = 7.0 years). There was no significant difference in the mean plasma levels of alanine transaminase (ALT), alkaline phosphatase, and gamma glutamyl transferase across the three groups of children. The mean aspartate transaminase level was significantly higher in children in group III. There was a statistically significant negative correlation between the duration of AED therapy and the mean serum level of AST (r = -0.266, P = 0.016). The serum ALT level showed a statistically significant positive correlation with the duration of AED therapy (r = 0.268, P = 0.015). CONCLUSION Sodium valproate monotherapy does not appear to be associated with significant hepatotoxicity in children in our cohort.

中文翻译：

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丙戊酸钠治疗癫痫患儿肝酶水平的非剂量依赖性变化。

背景丙戊酸钠（VPA）被认为是治疗儿童全身性癫痫的首选药物。丙戊酸钠可能具有肝毒性。目的 评估丙戊酸钠治疗癫痫患儿的肝酶紊乱水平。方法 队列研究。153 名儿童，包括 51 名接受 VPA 治疗的癫痫患者（第 I 组）、51 名接受其他抗癫痫药物 (AED) 但未接受 VPA 治疗的癫痫患者（第 II 组）和 51 名患有非惊厥性疾病的儿童（第 III 组）为他们进行的肝功能检查。数据采用SPSS 23.0版进行分析。结果男85例，女68例，年龄6个月～14岁（中位数=7.0岁）。丙氨酸转氨酶（ALT）、碱性磷酸酶、三组儿童的γ谷氨酰转移酶。III 组儿童的平均天冬氨酸转氨酶水平显着升高。AED 治疗时间与血清 AST 平均水平呈显着负相关（r = -0.266，P = 0.016）。血清ALT水平与AED治疗时间呈显着正相关（r = 0.268，P = 0.015）。结论 丙戊酸钠单一疗法似乎与我们队列中儿童的显着肝毒性无关。血清ALT水平与AED治疗时间呈显着正相关（r = 0.268，P = 0.015）。结论 丙戊酸钠单一疗法似乎与我们队列中儿童的显着肝毒性无关。血清ALT水平与AED治疗时间呈显着正相关（r = 0.268，P = 0.015）。结论 丙戊酸钠单一疗法似乎与我们队列中儿童的显着肝毒性无关。