The bionanocomposite hydrogels based on polyvinyl alcohol and egg white (as the matrix) and montmorillonite nanoclay (as reinforcement) were fabricated via the freezing-thawing technique. The prepared bionanocomposite hydrogels were loaded with clindamycin, as an effective antibiotic, to attain new potential wound dressings for healing the infected wounds. The microstructural properties of the bionanocomposite hydrogel wound dressings were characterized using the X-ray diffractometry, transmission electron microscopy, atomic force microscopy and gel fraction measurement. It was shown that all of the bionanocomposite hydrogel wound dressings had an exfoliated morphology and the montmorillonite layers acted as additional crosslinking zones to interconnect the polyvinyl alcohol and egg white chains. The characteristics of the prepared wound dressings were investigated using different experiments, including the water content, drying, water vapor transmission rate (WVTR), transparency and in vitro drug release tests. It was found that the equilibrium water content and WVTR were tended to decrease by increasing the loading level of montmorillonite in samples. The results showed that the drying period of bionanocomposite hydrogel wound dressings was prolonged by increasing the content of the incorporated montmorillonite. In vitro drug delivery experiments showed the cumulative fractional release of clindamycin and the clindamycin diffusion coefficient were decreased either by increasing the weight percentage of the incorporated montmorillonite into the wound dressings or by decreasing the pH of the release medium. It was also shown that the mechanism governing the release of clindamycin in all examined samples was the non-Fickian (anomalous) transport.

该bionanocomposite通过冻融技术制备了基于聚乙烯醇和蛋清（作为基质）和蒙脱石纳米粘土（作为增强剂）的水凝胶。制备的生物纳米复合水凝胶负载克林霉素作为一种有效的抗生素，以获得新的潜在伤口敷料来治愈感染的伤口。使用 X 射线衍射、透射电子显微镜、原子力显微镜和凝胶分数测量表征了生物纳米复合水凝胶伤口敷料的微观结构特性。结果表明，所有的生物纳米复合水凝胶伤口敷料都具有剥落的形态，蒙脱石层作为额外的交联区，将聚乙烯醇和蛋清链相互连接起来。体外药物释放试验。发现随着蒙脱石在样品中的负载量的增加，平衡水含量和WVTR趋于降低。结果表明，通过增加蒙脱石的掺入量，可以延长生物纳米复合水凝胶伤口敷料的干燥时间。体外药物递送实验表明，克林霉素的累积分数释放和克林霉素扩散系数通过增加掺入伤口敷料的蒙脱石的重量百分比或通过降低释放介质的 pH 值而降低。还表明，控制所有检查样品中克林霉素释放的机制是非 Fickian（异常）运输。