In children who receive neurotoxic chemotherapy, peripheral neurotoxicity occurs frequently, necessitates dose reduction or treatment cessation, and affects function and long-term quality of life. No treatments exist for peripheral neurotoxicity and few assessment measures are specific to children. We did a systematic review to analyse the published literature concerning the evaluation of assessment measures for paediatric chemotherapy-induced peripheral neurotoxicity. We searched PubMed, CINAHL, PsycINFO, and Embase on Nov 7-8, 2018; of 1409 articles, seven met the inclusion criteria. A total of 335 children (excluding ten healthy controls) were enrolled in the seven studies and the sample sizes ranged from 17 to 86 individuals. 276 (82%) of the 335 children were actively undergoing chemotherapy treatment. Most studies did not comprehensively evaluate the psychometric properties of assessment measures for chemotherapy-induced peripheral neurotoxicity. By use of a narrative analysis that combined approaches from the Joanna Briggs Institute (Adelaide, SA, Australia) and the quality of diagnostic accuracy studies assessment method (known as QUADAS), only one study was deemed high quality. We identified two variants of the Total Neuropathy Score, two grading scales, two semi-objective tests, one patient-reported outcome, and several mobility measures. The National Cancer Institute Common Terminology Criteria for Adverse Events and the Balis grading scales showed lower sensitivity and specificity than the items of the Total Neuropathy Score. Although there is insufficient evidence to support the use of most approaches to assess chemotherapy-induced peripheral neurotoxicity in children, two variants of the Total Neuropathy Score, the pediatric-modified Total Neuropathy Score and the Total Neuropathy Score-pediatric vincristine, are promising but require further testing. Other approaches are less sensitive or less feasible. A patient-reported outcome measure for chemotherapy-induced peripheral neurotoxicity in children is needed.

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测量儿童化疗引起的周围神经毒性的方法：系统综述。

在接受神经毒性化学疗法的儿童中，周围神经毒性经常发生，需要减少剂量或停止治疗，并影响功能和长期生活质量。尚无针对周围神经毒性的治疗方法，针对儿童的评估措施很少。我们进行了系统的综述，以分析有关评估儿科化疗药物引起的周围神经毒性评估措施的文献。我们于2018年11月7日至8日搜索了PubMed，CINAHL，PsycINFO和Embase; 在1409篇文章中，有7篇符合纳入标准。七项研究共纳入335名儿童（不包括十名健康对照者），样本量为17至86个人。335名儿童中有276名（82％）正在积极接受化学疗法治疗。大多数研究并未全面评估针对化学疗法诱发的周围神经毒性的评估措施的心理计量学特性。通过结合Joanna Briggs研究所（澳大利亚阿德莱德，澳大利亚）的方法和诊断准确性研究评估方法（称为QUADAS）的质量的叙述分析，只有一项研究被认为是高质量的。我们确定了总神经病评分的两个变体，两个等级量表，两个半客观测试，一个患者报告的结局以及几种活动性指标。美国国家癌症研究所不良事件通用术语标准和Balis评分量表显示，其敏感性和特异性低于总神经病评分项目。尽管没有足够的证据支持使用大多数方法评估儿童化疗引起的周围神经毒性，但总神经病评分的两种变体，即儿科改良总神经病评分和总神经病评分-儿童长春新碱，是有希望的，但需要进一步测试。其他方法不太敏感或不太可行。需要一项针对儿童化疗引起的周围神经毒性的患者报告结局指标。