In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon- Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.

近年来，混合系统因其在药物开发中的各种生物学应用而受到广泛关注。通常，杂化分子由不同的分子实体构建，以产生具有改进生物活性的新功能分子。已经存在大量基于非类固醇和类固醇框架的天然杂合分子，它们通过混合生物合成途径由自然界合成，例如，a) 不同生物合成途径的整合或 b) 衍生的不同成分之间的碳-碳键形成通过不同的生物合成途径。多组分反应是生成具有高度多样性的高效杂化化合物库的好方法。在整个科学史上，开发技术的最常见因素是能源消耗少和避免使用危险试剂。在这种情况下，微波能量在化学转化中起着至关重要的作用，因为它涉及两个非常重要的合成标准，最大限度地减少加热所需的能量消耗和反应所需的时间。本综述总结了微波能量在甾体和非甾体杂化分子合成中的应用以及多组分反应的应用。