T cells able to control neoplasia or chronic infections display a signature gene expression profile similar or identical to that of central memory T cells. These cells have qualities of self-renewal and a plasticity that allow them to repeatedly undergo activation (growth, proliferation, and differentiation), followed by quiescence. It is these qualities that define the ability of T cells to establish an equilibrium with chronic infectious agents, and also preserve the ability of T cells to be re-activated (by checkpoint therapy) in response to malignant cancers. Here we describe distinctions between the forms of inhibition mediated by tumors and persistent viruses, we review the properties of T cells associated with long-term immunity, and we identify the transcription factor, FOXO1, as the control point for a program of gene expression that allows CD8+ T cells to undergo serial reactivation and self-renewal.

中文翻译：

---

T细胞对慢性感染和肿瘤反应的关键控制点：FOXO1。

能够控制肿瘤或慢性感染的 T 细胞显示出与中央记忆 T 细胞相似或相同的特征基因表达谱。这些细胞具有自我更新的特性和可塑性，使它们能够反复经历激活（生长、增殖和分化），然后进入静止状态。正是这些品质定义了 T 细胞与慢性感染因子建立平衡的能力，并且还保留了 T 细胞被重新激活（通过检查点疗法）以应对恶性癌症的能力。在这里，我们描述了由肿瘤和持久性病毒介导的抑制形式之间的区别，我们回顾了与长期免疫相关的 T 细胞的特性，我们确定了转录因子 FOXO1，