Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning (F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques represent therefore promising approaches for the future management of PanNETs. We conducted a systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis, the prognosis and the detection of therapeutic targets. However, further studies are required. It is also warranted to standardize the analysis methods and the collection techniques, in order to validate proteins with a relevance in the personalized approach to PanNETs management.

胰腺神经内分泌肿瘤（PanNETs）是罕见的肿瘤，通常表现为轻度行为，但有时具有不可预测的侵袭性。PanNETs通常是无功能的（NF），无法产生功能激素，而10-30％的PanNETs是功能正常的（F）-PanNET，例如胰岛素瘤，胃泌素瘤和其他罕见肿瘤。诊断和预后指标，以及新的治疗目标，仍然缺乏。因此，蛋白质组学技术代表了PanNET未来管理的有前途的方法。我们进行了系统的综述，以总结PanNETs中蛋白质组学的最新状况。总共包括9项研究，重点是NF-和F-PanNETs。的确，蛋白质组学对于诊断，预后和检测治疗靶标很有用。但是，需要进一步的研究。