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Prognostic Role of microRNA-205 in Human Gynecological Cancer: A Meta-Analysis of Fourteen Studies.
DNA and Cell Biology ( IF 3.1 ) Pub Date : 2020-05-08 , DOI: 10.1089/dna.2019.5316
Zhixi Wu 1 , Hong Tang 2 , Qian Xiong 3 , Dong Liu 3 , Tingting Xia 4 , Huichao Liang 5 , Qingjian Ye 3
Affiliation  

Several studies have revealed that miR-205 plays important roles in the development of gynecological cancers and thus may serve as a potential prognostic biomarker, but the current conclusions remain controversial. Therefore, the goal of this study was to explore the prognostic significance and functional mechanisms of miR-205 based on a meta-analysis and bioinformatics investigation. A total of 14 published studies containing 5835 patients were enrolled by searching the PubMed, EMBASE, and Cochrane library databases, 13 (14 datasets) and 5 (6 datasets) of which evaluated the correlations between the expression level of miR-205 and overall survival (OS) or disease-free survival (DFS)/disease-specific survival (DSS)/progression-free survival (PFS)/distant metastasis-free survival (DMFS), respectively. Furthermore, the use of online Kaplan–Meier plotter database analysis supplemented another seven results for OS. Then, a meta-analysis using these 21 and 6 datasets was performed. As a result, the overall analysis failed to demonstrate any significant associations between miR-205 expression and OS (p = 0.267) or DSS/DFS/DMFS/PFS (p = 0.457), but the subgroup analysis suggested that elevated miR-205 predicted a reduced OS for breast cancer (BC) patients (hazard ratio [HR] = 0.84, 95% confidence interval [CI] = 0.72–0.98; p = 0.022), while higher miR-205 was associated with a poor DSS for endometrial cancer (EC) patients (HR = 2.19, 95% CI = 1.45–3.32; p < 0.001). Function prediction analysis indicated that miR-205 may be involved in BC by negatively influencing hub genes, SMARCA5 and SIAH1, whereas miR-205 may participate in EC by negatively modulating BMPR1B because of the presence of interactions of miR-205 with them at 3′-untranslated region and their opposite prognosis outcomes with miR-205. In conclusion, our findings suggest miR-205 may be a promising prognostic biomarker and therapeutic target for BC and EC patients.

中文翻译:

microRNA-205在人类妇科癌症中的预后作用:一项十四项研究的荟萃分析。

多项研究表明,miR-205在妇科癌症的发展中起着重要作用,因此可能作为潜在的预后生物标志物,但目前的结论仍存在争议。因此,本研究的目的是基于荟萃分析和生物信息学研究,探讨miR-205的预后意义和功能机制。通过搜索PubMed,EMBASE和Cochrane库数据库共纳入14项包含5835名患者的研究,其中13项(14个数据集)和5项(6个数据集)评估了miR-205表达水平与总生存率之间的相关性(OS)或无病生存期(DFS)/疾病特异性生存期(DSS)/无进展生存期(PFS)/远处无转移生存期(DMFS)。此外,在线Kaplan–Meier绘图仪数据库分析的使用补充了OS的另外七个结果。然后,使用这21和6个数据集进行了荟萃分析。结果,整体分析未能证明miR-205表达与OS之间存在任何重要关联(p  = 0.267)或DSS / DFS / DMFS / PFS(p  = 0.457),但亚组分析表明,miR-205升高可预测乳腺癌(BC)患者的OS降低(危险比[HR] = 0.84,95%置信区间[CI] = 0.72–0.98;p  = 0.022),而较高的miR-205与子宫内膜癌(EC)患者DSS差相关(HR = 2.19,95%CI = 1.45–3.32;p  <0.001) 。功能预测分析表明,miR-205可能通过负面影响中心基因SMARCA5SIAH1参与BC ,而miR-205可能通过负面调节BMPR1B参与EC。因为在3'非翻译区存在miR-205与它们的相互作用,并且与miR-205的预后相反。总之,我们的研究结果表明miR-205可能是BC和EC患者的有希望的预后生物标志物和治疗靶标。
更新日期:2020-05-08
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