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Mathematical modelling of the role of mucosal vaccine on the within-host dynamics of Chlamydia trachomatis.
Journal of Theoretical Biology ( IF 2 ) Pub Date : 2020-04-18 , DOI: 10.1016/j.jtbi.2020.110291
Morenikeji Deborah Akinlotan 1 , Dann G Mallet 1 , Robyn P Araujo 1
Affiliation  

A mathematical model of the within-host replicative dynamics of C. trachomatis infection and its interactions with the immune system, in the presence of a mucosal vaccine, is presented. Our aim is to estimate the requisite efficacy of an efficacious mucosal vaccine that could promote a stable disease-free state in vivo. Sensitivity analysis was used to quantify how variability in the model parameters influence the value of the disease threshold R0. This shows that the two most important factors to be considered for achieving a disease-free state state in vivo, based on their influence on R0, are the efficacy of the Chlamydia vaccine, and the rate at which the humoral immune response protects healthy epithelial cells from infection. Numerical simulations of the model show that a vaccine with a minimum efficacy of 86% may be required for the in vivo control of Chlamydia burden. Such effective but imperfect Chlamydia vaccine could confer long-term protective immunity to genital Chlamydia infections. Conditions under which lower vaccine efficacies may suffice are also explored.

中文翻译:

粘膜疫苗对沙眼衣原体宿主内动力学作用的数学建模。

介绍了在存在粘膜疫苗的情况下,沙眼衣原体感染的宿主内复制动力学及其与免疫系统的相互作用的数学模型。我们的目标是评估一种有效的粘膜疫苗的必要功效,这种疫苗可以促进体内稳定的无病状态。敏感性分析用于量化模型参数的可变性如何影响疾病阈值 R0 的值。这表明,根据它们对 R0 的影响,在体内实现无病状态需要考虑的两个最重要因素是衣原体疫苗的功效和体液免疫反应保护健康上皮细胞的速率从感染。该模型的数值模拟表明,体内控制衣原体负荷可能需要最低效力为 86% 的疫苗。这种有效但不完美的衣原体疫苗可以赋予生殖器衣原体感染的长期保护性免疫。还探讨了较低的疫苗效力可能足以满足的条件。
更新日期:2020-04-18
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