Radix Paeoniae Alba is widely used in Chinese traditional medicine to treat various diseases such as gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In this paper, a novel acidic polysaccharide RPAPS purified from Radix Paeoniae Alba was evaluated for its structural features and potential of immunomodulatory and antioxidant activities. RPAPS (molecular weight: 1.0× 10⁵ Da) was mainly composed of α-(1 → 4)-Glcp, α-Arap, α-Galp, α-Rhap, β-D-Glcp, α-(1 → 6)-linked Glcp and GalA. Immunological tests indicated that RPAPS could improve RAW264.7 phagocytic activity and LPS-induced splenocyte proliferation. For antioxidant activities, RPAPS showed reducing power and DPPH scavenging activity in dose dependent. Moreover, RPAPS could significantly protect the PC12 cells from H₂O₂ damage. These data implied polysaccharides RPAPS had the potential to be novel natural antioxidative and immunopotentiating agents for using in functional foods or medicine.

中文翻译：

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一种新型白芍酸性多糖的免疫调节和抗氧化活性。

白芍在中药中被广泛用于治疗各种疾病，如胃肠道疾病、免疫调节、癌症和其他疾病。在本文中，评估了从白芍中纯化的新型酸性多糖 RPAPS 的结构特征以及免疫调节和抗氧化活性的潜力。RPAPS（分子量：1.0×10 ⁵  Da）主要由α-（1→4）-Glc p、α-Ara p、α-Gal p、α-Rha p、β-D-Glc p、α-组成(1 → 6)-连接的 Glc p和 GalA。免疫学测试表明，RPAPS 可以提高 RAW264.7 的吞噬活性和 LPS 诱导的脾细胞增殖。对于抗氧化活性，RPAPS 显示出剂量依赖性的降低能力和 DPPH 清除活性。此外，RPAPS可以显着保护PC12细胞免受H ₂ O ₂损伤。这些数据表明多糖 RPAPS 有可能成为用于功能性食品或药物的新型天然抗氧化和免疫增强剂。