Background. Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed. Methods. we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment. Results. Eighty-seven people with schizophrenia were included and allocated to either the RR group (n = 57) or the TR group (n = 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP], p < 0.001, d = 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative, p < 0.001, d = 0.827; PANSS GP, p < 0.001, d = 0.991; PANSS positive, p = 0.009, d = 0.594), verbal abstraction (p = 0.008, d = 0.554), aggression bias (p = 0.008, d = 0.627), and self-stigma (stereotype endorsement, p = 0.019, d = 0.495; discrimination experiences, p = 0.047; d = 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up. Conclusions. Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness.

中文翻译：

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通过精神分裂症的真实社会认知矫正改善社会功能：来自 RemedRugby 准实验性试验的结果

背景。功能能力 (FC) 已被确定为改善精神分裂症现实世界功能的关键结果。FC 受认知障碍、阴性症状、自我污名和体力活动 (PA) 减少的影响。针对 FC 的社会心理干预措施仍不完善。方法。我们进行了一项准实验性研究，评估了锻炼丰富的综合社会认知矫正 (SCR) 干预 (RemedRugby [RR]) 与练习触摸橄榄球 (TR) 的主动对照组的效果。据我们所知，这是迄今为止第一次评估在现实环境中提供的此类程序的有效性的试验。结果。根据招募中心的常规临床实践，87 名精神分裂症患者被纳入并分配到 RR 组（n = 57）或 TR 组（n = 30）。两组在基线和治疗后以及 RR 组在随访 6 个月后使用症状严重程度、社会功能、自我污名和大认知电池的标准化量表评估结果。治疗后，我们观察到社会功能（个人和社会表现量表 [PSP]，p < 0.001，d = 1.255）、症状严重程度（阳性和阴性综合征量表 [PANSS] 阴性，p < 0.001，d = 0.827）有中到大的改善; PANSS GP, p < 0.001, d = 0.991; PANSS 阳性, p = 0.009, d = 0.594), 语言抽象 (p = 0.008, d = 0.554), 攻击性偏见 (p = 0.008, d = 0.627), 0.627 和自我污名（刻板印象，p = 0.019，d = 0.495；歧视经历，p = 0.047；d = 0.389），这是 RR 组特有的，并且在只玩 TR 的参与者中没有观察到。随着时间的推移，影响会持续存在，甚至在治疗后和随访之间影响更大。结论。富含运动的综合 SCR 似乎有望改善精神分裂症的现实生活功能。未来的研究应该调查这种干预对神经可塑性和身体健康的潜在影响。富含运动的综合 SCR 似乎有望改善精神分裂症的现实生活功能。未来的研究应该调查这种干预对神经可塑性和身体健康的潜在影响。富含运动的综合 SCR 似乎有望改善精神分裂症的现实生活功能。未来的研究应该调查这种干预对神经可塑性和身体健康的潜在影响。