Quinones are a huge class of compounds with affluent and captivating chemistry. p-Benzoquinone (p-BNZ) or 1,4-Benzoquinone is the key structural motif of numerous biologically active synthetic and natural compounds. This draws interest in its biological exploration to assess prospective therapeutic implications. It possesses immense therapeutic potential depending on different substitutions. This moiety has a marvelous potential to regulate a varied range of different cellular pathways which can be investigated for various selective activities. p-Benzoquinones have been a requisite core for the development of novel therapeutic molecules with minimum side effects. In this review, various synthetic, pharmacological approaches and structure-activity relationship studies focusing on the chemical groups responsible for evoking the pharmacological potential of p-benzoquinone derivatives have been emphasized. Additionally, the compilation highlights the chemical, pharmaceutical and medicinal aspects of synthetic and natural benzoquinone derivatives. The natural occurrences of p-benzoquinone derivatives with different pharmacological significance have also been reported in this review.

醌是一类具有丰富和迷人化学性质的化合物。对苯醌（p-BNZ）或1,4-苯醌是许多具有生物活性的合成和天然化合物的关键结构基序。这引起了对其生物学探索以评估预期治疗意义的兴趣。根据不同的替代方法，它具有巨大的治疗潜力。该部分具有奇妙的潜力来调节不同范围的不同细胞途径，可以研究其各种选择性活性。对苯醌一直是开发具有最小副作用的新型治疗分子的必不可少的核心。在这篇评论中，各种合成，重点强调了引起对-苯醌衍生物药理潜力的化学基团的药理方法和结构-活性关系研究。此外，该汇编重点介绍了合成和天然苯醌衍生物的化学，药物和药用方面。这篇综述还报道了具有不同药理学意义的对苯醌衍生物的天然存在。