Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2020-10-31 , DOI: 10.2174/1389557520666200429101053 Abhinay Thakur 1 , Rohit Sharma 2 , Vivek Sheel Jaswal 3 , Eugenie Nepovimova 4 , Ashun Chaudhary 5 , Kamil Kuca 4
Coumarin belongs to a class of lactones that are fundamentally comprised of a benzene ring fused to an α-pyrone ring; these lactones are known as benzopyrones. Similarly, coumarin has a conjugated electron-rich framework and good charge-transport properties. Plants produce coumarin as a chemical response to protect themselves from predation. Coumarins are used in different products, such as cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks, and they play a relevant role in natural products and in organic and medicinal chemistry. In addition, as candidate drugs, many coumarin compounds have strong pharmacological activity, low toxicity, high bioavailability and better curative effects and have been used to treat various types of diseases. Various endeavors were made to create coumarin-based anticoagulant, antimicrobial, antioxidant, anticancer, antidiabetic, antineurodegenerative, analgesic and anti-inflammatory agents. A class of chemical compounds called furocoumarins has phototoxic properties and is naturally synthesized via the fusion of coumarin to a furan ring in different plant species. Psoralens belong to the furocoumarin class and occur naturally in various plants, e.g., lemons, limes, and parsnips. Angelicin is an isomer of psoralens, and most furocoumarins, e.g., xanthotoxin, bergapten, and nodekenetin, are derivatives of psoralens or angelicin. The present work demonstrated that psoralen molecules exhibit anti-tumoral activity against breast cancer and influence different intracellular signals to maintain the high survival of breast cancer cells. Psoralens perform different functions, e.g., antagonize metabolic pathways, protease enzymes, and cell cycle progression and even interfere in the crosslinking between receptors and growth factor mitogenic signaling.
中文翻译:
补骨脂素:具有重要应用的生物重要香豆素。
香豆素属于一类内酯,基本上由与α-吡喃酮环稠合的苯环组成。这些内酯称为苯并吡喃酮。同样,香豆素具有共轭富电子骨架和良好的电荷传输性能。植物产生香豆素是一种化学反应,可以保护自己免受捕食。香豆素可用于各种产品中,例如化妆品,添加剂,香水,各种烟草和某些酒精饮料中的增香剂,它们在天然产品以及有机和药物化学中起着重要的作用。此外,作为候选药物,许多香豆素化合物具有强的药理活性,低毒性,高生物利用度和更好的疗效,并且已经被用于治疗各种类型的疾病。为了产生基于香豆素的抗凝剂,人们进行了各种努力,抗菌剂,抗氧化剂,抗癌剂,抗糖尿病药,抗神经变性剂,镇痛药和消炎药。一类称为呋喃香豆素的化合物具有光毒性,是通过香豆素与不同植物物种中的呋喃环融合而天然合成的。补骨脂素属于呋喃香豆素类,天然存在于各种植物中,例如柠檬,酸橙和欧洲防风草。当归霉素是补骨脂素的一种异构体,大多数呋喃香豆素,例如黄嘌呤毒素,佛手柑和结节酮,是补骨脂素或当归霉素的衍生物。目前的工作表明补骨脂素分子表现出抗乳腺癌的抗肿瘤活性,并影响不同的细胞内信号,以维持乳腺癌细胞的高存活率。补骨脂素执行不同的功能,例如拮抗代谢途径,