Few quantitative behavior genetic studies have examined why psychopathology is associated with suicide attempt (SA) and self-harm (SH) in adolescence. The present study analyzed data from the Child and Adolescent Twin Study in Sweden to examine the extent to which genetic and environmental factors explain SA/SH and its association with psychopathology in childhood, an often-cited risk factor of subsequent SA/SH. When children were 9 or 12 years old (n = 30,444), parents completed the Autism-Tics, AD/HD and other Comorbidities Inventory (Larson et al., 2010) regarding their children's psychiatric problems as part of an ongoing, longitudinal study. At age 18 years (n = 10,269), adolescents completed self-report questionnaires, including SA/SH assessments. In a bifactor model of childhood psychopathology, a general factor of psychopathology was a statistically significant predictor of adolescent SA/SH at a higher magnitude (β, 0.25, 95% confidence interval [CI; 0.15, 0.34] for suicide attempt), as compared with specific factors of inattention, impulsivity, oppositional behavior, and anxiety/emotion symptoms. Quantitative genetic modeling indicated that the additive genetic influences on the general factor accounted for the association with each outcome (β, 0.24, 95% CI [0.13, 0.34] for suicide attempt). The results remained virtually identical when we fit a higher order factors model. Two additional outcomes demonstrated comparable results. The results extend current literature by revealing the shared genetic overlap between general psychopathology during childhood and adolescent SA/SH. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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一般儿童精神病理学与青少年自杀企图和自残之间的关联：一项基于人群的前瞻性双胞胎研究。

很少有定量行为遗传学研究探讨了为什么精神病理学与青春期自杀企图（SA）和自残（SH）有关。本研究分析了瑞典儿童和青少年双胞胎研究的数据，以检验遗传和环境因素在多大程度上解释 SA/SH 及其与儿童时期精神病理学的关系，这是随后 SA/SH 的一个经常被引用的危险因素。当孩子 9 岁或 12 岁时（n = 30,444），父母完成了关于孩子精神问题的自闭症抽动症、AD/HD 和其他合并症调查表（Larson 等，2010），作为正在进行的纵向研究的一部分。青少年在 18 岁时（n = 10,269）完成了自我报告问卷，包括 SA/SH 评估。在儿童精神病理学的双因素模型中，精神病理学的一般因素是青少年 SA/SH 的统计显着预测因子（自杀未遂的β，0.25，95％置信区间 [CI；0.15，0.34]）。具有注意力不集中、冲动、对抗行为和焦虑/情绪症状等特定因素。定量遗传模型表明，对一般因素的加性遗传影响解释了与每个结果的关联（对于自杀企图，β，0.24，95% CI [0.13，0.34]）。当我们拟合高阶因子模型时，结果几乎保持不变。另外两个结果显示了类似的结果。这些结果通过揭示儿童期和青少年 SA/SH 期间的一般精神病理学之间共有的遗传重叠来扩展现有文献。（PsycInfo 数据库记录 (c) 2020 APA，保留所有权利）。