AIM To assess the outcomes of platelet-rich plasma as a scaffold in regenerative/revitalization endodontics (RET) using cone beam computed tomography (CBCT) and 2-dimensional radiographs. METHODOLOGY Twenty-six healthy patients with mean age of 12.66 ± 4.47, and immature permanent anterior teeth with necrotic pulps, were randomly allocated to two groups, whereby RET was performed using platelet-rich plasma (PRP, test group) and blood clot (BLC, control group). Changes in root length (RL), root dentinal thickness (RDT), apical foramen width (AFW) and radiographic root area (RRA), were assessed using both radiographic methods, whilst changes in periapical area diameter (PAD) were assessed using CBCT, over a period of 12 months. T-test and chi-square/Fisher's exact tests were used to compare continuous and categorical data between BLC and PRP groups, respectively. Changes in RL, RDT, AFW, RRA and PAD were examined by comparing the two groups (PRP versus BLC) using multilevel modelling, considering the clustering effect of repeated measures of several teeth originating from the same participant. RESULTS Changes in RL, RDT, AFW, RRA and PAD, over time, were found to be significant for both groups. There was, however, no difference between the RET techniques (PRP versus BLC), using both radiographic and CBCT methods. The results of both assessment techniques (CBCT and 2-dimensional radiographic methods) were highly consistent (overall ICC ranged between 0.80 and 0.94). In addition, a significant effect of baseline PAD was found on RL, RRA and AD at 12 months (RL effect = -0.68, P < 0.001; RRA effect = -1.91, P = 0.025; AD effect = 0.08, P = 0.024). CONCLUSION The current study highlights successful and comparable clinical and radiographic outcomes of RET techniques using PRP and BLC. Standardized and calibrated 2-dimensional radiographic assessment was as effective as CBCT in assessing RET outcomes; therefore, the routine use of CBCT in RET is not recommended. Although an effect of baseline periapical lesion diameter on root development outcomes, at 12 months, were observed, more studies are recommended in order to assess such an effect.

中文翻译：

---

使用二维X射线照片和锥束计算机断层扫描评估了富含血小板的血浆作为支架对未成熟恒牙的再生/活化牙髓的作用：一项随机对照试验。

目的使用锥束计算机断层扫描（CBCT）和二维射线照相技术评估再生/活化牙髓学（RET）中作为支架的富血小板血浆的结果。方法将26例平均年龄为12.66±4.47，未成熟前牙带坏死牙髓的健康患者随机分为两组，分别采用富血小板血浆（PRP，测试组）和血凝块（BLC）进行RET ， 控制组）。两种射线照相方法均评估了牙根长度（RL），牙根厚度（RDT），根尖孔宽度（AFW）和放射线根部面积（RRA）的变化，而使用CBCT评估了根尖周直径（PAD）的变化，在12个月内。T检验和卡方检验/ Fisher' 的精确测试分别用于比较BLC组和PRP组之间的连续数据和分类数据。考虑到同一参与者多颗牙齿重复测量的聚类效果，通过多级建模比较两组（PRP与BLC）来检查RL，RDT​​，AFW，RRA和PAD的变化。结果发现，随时间推移，RL，RDT​​，AFW，RRA和PAD的变化对两组均具有显着影响。但是，使用射线照相和CBCT方法的RET技术（PRP与BLC）之间没有差异。两种评估技术（CBCT和二维射线照相方法）的结果高度一致（总体ICC介于0.80至0.94之间）。此外，在12个月时发现基线PAD对RL，RRA和AD有显着影响（RL影响= -0.68，P <0.001；RRA效应= -1.91，P = 0.025; AD效应= 0.08，P = 0.024）。结论当前的研究强调了使用PRP和BLC的RET技术的成功和可比较的临床和放射学结果。标准化和校准的二维放射线评估在评估RET结果方面与CBCT一样有效。因此，不建议在RET中常规使用CBCT。尽管在12个月时观察到了根尖周根部病变直径对根发育结果的影响，但建议进行更多研究以评估这种作用。标准化和校准的二维放射线评估在评估RET结果方面与CBCT一样有效。因此，不建议在RET中常规使用CBCT。尽管在12个月时观察到了根尖周根部病变直径对根发育结果的影响，但建议进行更多研究以评估这种作用。标准化和校准的二维放射线评估在评估RET结果方面与CBCT一样有效。因此，不建议在RET中常规使用CBCT。尽管在12个月时观察到了根尖周根部病变直径对根发育结果的影响，但建议进行更多研究以评估这种作用。