Abstract

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don’t suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over.

摘要

当前的COVID-19大流行是最近历史上最具破坏性的事件之一。该病毒对年轻健康的人群造成相对较小的损害，对老年人和患有慢性炎症的人构成威胁生命的危险。因此，如果我们能够减少弱势群体的风险，那将使COVID-19大流行与其他典型的暴发更加相似。儿童遭受的COVID-19痛苦不及其祖父母那么多，褪黑激素水平更高。蝙蝠是夜间活动的动物，其褪黑激素水平很高，这可能有助于它们提高抗病毒能力。病毒会诱发炎症性细胞因子和活性氧的爆炸，褪黑激素是随年龄而消失的最好的天然抗氧化剂。程序性细胞死亡冠状病毒会导致 褪黑素也可以抑制肺部受损。冠状病毒引起肺部炎症，需要炎症体活动。褪黑素可阻断这些炎症小体。焦虑和睡眠不足会削弱全身免疫力。褪黑素改善睡眠习惯，减少焦虑并刺激免疫力。纤维化可能是COVID-19之后最危险的并发症。众所周知，褪黑素可预防纤维化。机械通风可能是必需的，但由于氧化应激会带来风险，而褪黑激素可降低这种风险。因此，通过使用安全的非处方药褪黑激素，我们可以立即预防冠状病毒患者的严重疾病症状的发展，减轻其症状的严重程度，