Abstract

Objective: To evaluate the impact of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids on ovarian reserve in women of reproductive age.

Materials and methods: From September 2015 to September 2017, 84 patients with uterine fibroids in reproductive age were enrolled from Chongqing Haifu Hospital, Three Gorges Central Hospital of Chongqing and Aegisroen obstetric gynecology Clinic of Seoul, Korea. Blood was collected before HIFU treatment and 6 months after USgHIFU treatment. The enzyme-linked immune analysis was used for assay of circulating anti-Mullerian hormone (AMH).

Results: All the 84 patients were successfully treated with USgHIFU and 67 patients completed the follow-up. The median age of the 67 patients was 38 years at the time of treatment. The median AMH value before and 6 months after treatment was 1.26 ng/mL and 1.27 ng/mL, respectively. Patients who completed AMH measurements 6 months after treatment were further classified into three groups based on age, including younger than 35 years, 36 to 40 years, and older than 40 years. The median AMH values before treatment were 3.04 ng/mL, 1.73 ng/mL and 0.87 ng/mL, and the corresponding values 6 months after treatment were 3.24, 1.44 and 0.75, respectively. A significant difference in AMH level was observed in the group of patients at the age between 36 and 40 years (p < 0.05), but no significant difference in AMH levels was observed in the other two groups (p > 0.05).

Conclusion: Based on our results, we conclude that USgHIFU has no influence on ovarian reserve.

摘要

目的：评估超声引导高强度聚焦超声（USgHIFU）对子宫肌瘤对育龄妇女卵巢储备的影响。

材料与方法： 2015年9月至2017年9月，从重庆市海府医院，重庆市三峡中心医院和韩国首尔爱神罗恩妇产科门诊收治的84名育龄子宫肌瘤患者。HIFU治疗前和USgHIFU治疗后6个月采血。酶联免疫分析用于测定循环抗Mullerian激素（AMH）。

结果： 84例患者均成功接受USgHIFU治疗，其中67例完成了随访。在接受治疗时，这67名患者的中位年龄为38岁。治疗前和治疗后6个月的AMH中值分别为1.26 ng / mL和1.27 ng / mL。治疗后6个月完成AMH测量的患者根据年龄进一步分为三组，包括35岁以下，36至40岁和40岁以上。治疗前AMH的中位数为3.04 ng / mL，1.73 ng / mL和0.87 ng / mL，治疗6个月后的相应值分别为3.24、1.44和0.75。在36至40岁之间的患者组中，观察到AMH水平存在显着差异（p <0.05），但其他两组的AMH水平没有显着差异（p  > 0.05）。

结论：根据我们的结果，我们得出结论，USgHIFU对卵巢储备没有影响。