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Reprogramming Müller Glia to Regenerate Retinal Neurons.
Annual Review of Vision Science ( IF 6 ) Pub Date : 2020-09-16 , DOI: 10.1146/annurev-vision-121219-081808
Manuela Lahne 1, 2 , Mikiko Nagashima 3 , David R Hyde 1, 2 , Peter F Hitchcock 3, 4
Affiliation  

In humans, various genetic defects or age-related diseases, such as diabetic retinopathies, glaucoma, and macular degeneration, cause the death of retinal neurons and profound vision loss. One approach to treating these diseases is to utilize stem and progenitor cells to replace neurons in situ, with the expectation that new neurons will create new synaptic circuits or integrate into existing ones. Reprogramming non-neuronal cells in vivo into stem or progenitor cells is one strategy for replacing lost neurons. Zebrafish have become a valuable model for investigating cellular reprogramming and retinal regeneration. This review summarizes our current knowledge regarding spontaneous reprogramming of Müller glia in zebrafish and compares this knowledge to research efforts directed toward reprogramming Müller glia in mammals. Intensive research using these animal models has revealed shared molecular mechanisms that make Müller glia attractive targets for cellular reprogramming and highlighted the potential for curing degenerative retinal diseases from intrinsic cellular sources.

中文翻译:


重新编程 Müller Glia 以再生视网膜神经元。

在人类中,各种遗传缺陷或与年龄相关的疾病,如糖尿病视网膜病变、青光眼和黄斑变性,会导致视网膜神经元死亡和严重的视力丧失。治疗这些疾病的一种方法是利用干细胞和祖细胞原位替换神经元,期望新的神经元会产生新的突触回路或整合到现有的突触回路中。在体内将非神经元细胞重编程为干细胞或祖细胞是替代丢失神经元的一种策略。斑马鱼已成为研究细胞重编程和视网膜再生的宝贵模型。这篇综述总结了我们目前关于斑马鱼 Müller 胶质细胞自发重编程的知识,并将这些知识与针对哺乳动物 Müller 胶质细胞重编程的研究工作进行了比较。

更新日期:2020-09-18
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