A new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A–N (2–15), and a known irlactane-type sesquiterpenoid, were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102. The structures of all the isolates were characterized by extensive spectroscopic methods, including 1D and 2D NMR and MS spectroscopic analysis. The absolute configurations of irlactin K and the known compound conocenol B (20) were established by single-crystal X-ray diffraction analysis. The vasorelaxant effects of irlactin K (1), irpexolactins A (2), C (4), K (12), and irlactam (22) were evaluated.

Graphic Abstract

中文翻译：

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药用真菌Irpex lacteus HFG1102的培养物中的正十六烷和三聚草醚倍半萜。

一种新的irlactane型，即irlactin K（1），和22 tremulane型倍半萜包括14倍以前未描述的，即irpexolactins A-N（2 - 15），和一个公知的irlactane型倍半萜类，从发酵液中分离药用真菌Irpex lacteus HFG1102。所有分离物的结构都通过广泛的光谱方法进行了表征，包括1D和2D NMR和MS光谱分析。irlactin K和已知化合物conocenol B（20）的绝对构型通过单晶X射线衍射分析确定。irlactin K（1），irpexolactins A（2），C（）的血管舒张作用4），K（12）和irlactam（22）被评估。

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