Objective: The aim of this study was to assess health-related quality-of-life (HRQoL) in men and women operated on with radical cystectomy, compared to the general Norwegian population.

Materials and methods: All patients with bladder cancer who had undergone radical cystectomy (RC) between 2011–2017 and either received ileal conduit (IC) or orthotopic neobladder (ONB) as urinary diversion were included in a cross-sectional study. HRQoL and sociodemographic data was collected and measured with a questionnaire consisting of the generic EORTC QLQ-C30.v3 and the cancer specific EORTC QLQ-BLM30 and compared to a general population sample.

Results: Of the 220 invited patients, 173 patients (78.6%) returned the questionnaires. The global quality-of-life (QoL) score was comparable with the general population. Women had significantly higher fatigue score, worse future perspective and symptoms like bloating, compared to male patients. Men had significantly lower social functioning, more constipation, diarrhoea and sleep disturbance compared to the general male population. There was no significant difference in HRQoL domains between female patients and the general female population. A follow-up (FU) period longer than 37 months since surgery was associated with significantly improved physical- and role-functioning, less fatigue and fewer problems with the urostoma, compared to a shorter FU time.

Conclusion: This study found a high global QoL score after radical cystectomy, comparable with the general Norwegian population. Symptoms seem to improve over time. Difference in HRQoL outcomes between men and woman in the study population was comparable with the difference found in the general population.

目的：本研究的目的是评估与普通挪威人群相比，行根治性膀胱切除术的男性和女性的健康相关生活质量（HRQoL）。

材料和方法：所有横断面研究均包括所有在2011年至2017年之间接受了根治性膀胱切除术（RC）并接受回肠导管（IC）或原位新膀胱（ONB）导尿的膀胱癌患者。收集并使用由普通EORTC QLQ-C30.v3和癌症特异性EORTC QLQ-BLM30组成的问卷调查表收集HRQoL和社会人口统计学数据，并与一般人群样本进行比较。

结果：在220位邀请患者中，有173位患者（78.6％）返回了问卷。全球生活质量（QoL）得分与普通人群相当。与男性患者相比，女性具有明显更高的疲劳评分，较差的未来视力和腹胀等症状。与一般男性相比，男性的社交功能明显降低，便秘，腹泻和睡眠障碍更多。女性患者和普通女性人群之间的HRQoL域没有显着差异。自从手术以来，随访时间超过37个月，与之相比，手术时间明显缩短，与身体和角色功能的显着改善，疲劳和尿道瘤问题的减少相关。

结论：这项研究发现，根治性膀胱切除术后总体QoL评分较高，与普通挪威人群相当。症状似乎随着时间的推移而改善。研究人群中男女之间的HRQoL结果差异与一般人群中的差异相当。