In this paper, a novel l‐glutamate based immobilized chiral ionic liquid (SBA‐IL (Glu)) was prepared by chemical bonding method and applied as a solid sorbent for chiral separation of amlodipine. The performance of SBA‐IL (Glu) was investigated for the absorption of (S)‐amlodipine and separation of amlodipine enantiomer. The static experiment showed that equilibrium adsorption was achieved within 80 minutes, and the saturation adsorptions capacity was 12 mg/g. The complex was then packed in a glass chromatographic column for the separation of amlodipine and the enantiomeric excess (%ee) of (S)‐amlodipine reached 24.67%. The immobilized ionic liquids exhibit good reusability, and the separation efficiency remains 18.24% after reused five times, which allows potential scale‐up for the chiral separation of amlodipine.

中文翻译：

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外消旋氨氯地平的对映体分离，采用固相萃取固定化离子液体。

在本文中，一种新颖的升基于固定化手性离子液体（SBA-IL（谷氨酸））的制备是通过化学粘结方法和作为用于氨氯地平的手性分离固体吸附剂施加谷氨酸盐。研究了SBA-IL（Glu）在（S）-氨氯地平吸收和氨氯地平对映体分离中的性能。静态实验表明，在80分钟内达到了平衡吸附，饱和吸附容量为12 mg / g。然后将络合物装填在玻璃色谱柱中，以分离氨氯地平和（S的对映体过量（％ee）氨氯地平达到24.67％。固定的离子液体显示出良好的可重复使用性，重复使用五次后，分离效率保持18.24％，这有可能扩大氨氯地平的手性分离规模。