当前位置: X-MOL 学术Eur. J. Clin. Microbiol. Infect. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
European Journal of Clinical Microbiology & Infectious Diseases ( IF 4.5 ) Pub Date : 2020-04-27 , DOI: 10.1007/s10096-020-03913-9
Bernard La Scola 1, 2 , Marion Le Bideau 1, 2 , Julien Andreani 1, 2 , Van Thuan Hoang 1, 3, 4 , Clio Grimaldier 1, 2 , Philippe Colson 1, 2 , Philippe Gautret 1, 3 , Didier Raoult 1, 2
Affiliation  

In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.

中文翻译:

通过细胞培养确定的病毒RNA载量,作为将SARS-CoV-2患者从传染病病房中排出的一种管理工具。

在一项初步的临床研究中,我们观察到羟氯喹和阿奇霉素的组合可通过缩短Covid-19患者的病毒载量持续时间来有效对抗SARS-CoV-2。定义何时可以将被治疗的患者视为不再具有传染性至关重要。细胞培养物中病毒的成功分离与靶向E基因的定量RT-PCR的Ct值之间的相关性表明,使用我们的RT-PCR系统对Ct高于33-34的患者没有传染性,因此可以出院或严格限制非住院患者。
更新日期:2020-04-27
down
wechat
bug