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Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
Annual Review of Immunology ( IF 29.7 ) Pub Date : 2020-04-26 , DOI: 10.1146/annurev-immunol-080219-023629
Kathryn E Stephenson 1, 2 , Kshitij Wagh 3, 4 , Bette Korber 3, 4 , Dan H Barouch 1, 2
Affiliation  

Development of improved approaches for HIV-1 prevention will likely be required for a durable end to the global AIDS pandemic. Recent advances in preclinical studies and early phase clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1 infection. Clinical trials are currently underway to evaluate the efficacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection in humans. However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization. Here we review current immunologic strategies for HIV-1 prevention, with a focus on current and next-generation vaccines and bNAbs.

中文翻译:

用于预防 HIV-1 的疫苗和广泛中和抗体。

要持久结束全球艾滋病流行,可能需要开发改进的 HIV-1 预防方法。临床前研究和早期临床试验的最新进展为阻止 HIV-1 感染的免疫策略带来了新的希望。目前正在进行临床试验,以评估两种候选疫苗和一种广泛中和抗体 (bNAb) 预防人类 HIV-1 感染的功效。然而,HIV-1 的巨大多样性对主动和被动免疫都是一个重大挑战。在这里,我们回顾了当前预防 HIV-1 的免疫策略,重点关注当前和下一代疫苗和 bNAb。
更新日期:2020-04-26
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