B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.

中文翻译：

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B 淋巴细胞在心血管疾病中的新作用。

传统上，B 细胞以其在适应性免疫反应中产生抗体的能力而闻名。然而，在过去十年中，B 细胞越来越多地被认为是适应性和先天免疫反应的调节剂，并且在多种人类疾病的发病机制中发挥着重要作用。在这里，在简要总结我们目前对 B 细胞生物学的理解之后，我们对来自动物模型和人体研究的文献进行了系统回顾，这些文献强调了 B 淋巴细胞在心脏和血管疾病中的重要作用。虽然血管系统中 B 细胞生物学的许多方面以及在更大程度上心脏中的 B 细胞生物学的许多方面仍不清楚，但 B 细胞正在成为心血管适应损伤的关键调节剂。