Objective:Reward sensitivity is an increasingly used construct in psychiatry, yet its possible inner structure and relationship with other affective variables are not well known.Methods:A reward sensitivity measurement scale was constructed on the basis of large item pool collected from birth cohort representative samples (the Estonian Children Personality Behaviour and Health Study; original n = 1238). Affective Neuroscience Personality Scale (ANPS) and the Adult Attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS) were administered in young adulthood. A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped.Results:Reward sensitivity consisted of two orthogonal components, operationally defined as Openness to Rewards and Insatiability by Reward, that respectively characterise the striving towards multiple rewards and the strong pursuit and fixation to a particular reward. While SEEKING and PLAY (and to lower extent CARE) of the ANPS co-varied with Openness to Rewards, FEAR, SADNESS, and ANGER were related to Insatiability by Reward. The total score of ASRS was moderately correlated with Insatiability by Reward, while the association with Openness to Rewards was negligible. However, ASRS Inattention had some negative relationship with the Social Experience facet of Openness to Rewards. The T/T homozygotes for the TPH2 promoter polymorphism had lower Insatiability by Reward but not Openness to Rewards.Conclusions:Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention, and hyperactivity as well as to TPH2 genotype.

中文翻译：

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奖励敏感性、情感神经科学人格、注意力缺陷/多动障碍症状和 TPH2-703G/T (rs4570625) 基因型

目的：奖赏敏感性是精神病学中越来越多使用的结构，但其可能的内在结构以及与其他情感变量的关系尚不清楚。方法：基于出生队列代表性样本收集的大项目库，构建奖赏敏感性测量量表（爱沙尼亚儿童人格行为与健康研究；原创n= 1238)。情感神经科学人格量表 (ANPS) 和成人注意力缺陷多动障碍 (ADHD) 自我报告量表 (ASRS) 在青年期进行管理。编码色氨酸羟化酶 2 的基因的变体 (rs4570625) (TPH2) 对负责合成中枢血清素的基因进行了基因分型。结果：奖励敏感性由两个正交分量组成，在操作上定义为对奖励的开放性和对奖励的不满足性，它们分别表征了对多重奖励的追求和对一个事物的强烈追求和固着。特别的奖励。虽然 ANPS 的寻求和玩耍（以及较低程度的关心）与对奖励的开放性共同变化，但恐惧、悲伤和愤怒与奖励的不满足性有关。ASRS 的总分与 Insatiability by Reward 中度相关，而与 Openness to Rewards 的关联可以忽略不计。然而，ASRS 注意力不集中与奖励开放性的社会体验方面有一些负面关系。的 T/T 纯合子TPH2启动子多态性具有较低的奖励不满足性，但不具有奖励开放性。结论：对奖励敏感的行为与可变性和固定性成分是分开的，这些成分与人格、注意力和多动的情感方面以及与TPH2基因型。