ABSTRACT

Purpose: To investigate the effects of intrathecal baclofen therapy (ITB) on health-related quality of life for children with cerebral palsy and neurological conditions.

Method: This study is part of a longitudinal, multicentre audit. The primary outcome measure, the Caregiver Priorities and Child Health Index of Life with Disabilities, was completed at baseline, 6 and 12 months post ITB implant.

Results: Forty subjects with cerebral palsy and other neurological conditions demonstrated significant improvement in aspects of health-related quality of life following ITB therapy, mean change 42.3 (SD 14.9) at baseline to 53.3 (SD 14.7) at 12 months (p< .001).

Conclusion: Evidence to demonstrate the utility of ITB in pediatric populations beyond spasticity and dystonia reduction is limited. Our findings suggest that ITB improves aspects of quality of life, comfort, and ease of caregiving in children with cerebral palsy and other neurological conditions.

摘要

目的：探讨鞘内使用巴氯芬治疗（ITB）对脑瘫和神经系统疾病患儿健康相关生活质量的影响。

方法：该研究是纵向，多中心审核的一部分。主要结果指标，即残障者的照护者优先级和儿童健康指数，是在ITB植入后6个月和12个月完成的。

结果：40名患有脑瘫和其他神经系统疾病的受试者在ITB治疗后表现出健康相关生活质量方面的显着改善，基线时的平均变化为42.3（SD 14.9），至12个月时为53.3（SD 14.7）（p <.001 ）。

结论：除了痉挛和肌张力障碍减轻以外，证明ITB在儿科人群中的用途的证据有限。我们的发现表明，ITB可改善患有脑瘫和其他神经系统疾病的儿童的生活质量，舒适度和护理的便利性。